New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor.

@article{Wilcox1998NewDI,
  title={New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor.},
  author={Robert A. Wilcox and William U. Primrose and Stefan R. Nahorski and R. A. John Challiss},
  journal={Trends in pharmacological sciences},
  year={1998},
  volume={19 11},
  pages={
          467-75
        }
}
Receptor-mediated activation of phospholipase C to generate inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] is a ubiquitous signalling pathway in mammalian systems. A family of three IP3 receptor subtype monomers form functional tetramers, which act as effectors for Ins(1,4,5)P3, providing a ligand-gated channel that allows Ca2+ ions to move between cellular compartments. As IP3 receptors are located principally, although not exclusively, in the endoplasmic reticular membrane, Ins(1,4,5)P3 is… CONTINUE READING
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