New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor.

@article{Wilcox1998NewDI,
  title={New developments in the molecular pharmacology of the myo-inositol 1,4,5-trisphosphate receptor.},
  author={Robert A. Wilcox and William U. Primrose and Stefan R. Nahorski and R. A. John Challiss},
  journal={Trends in pharmacological sciences},
  year={1998},
  volume={19 11},
  pages={
          467-75
        }
}

• Robert A. Wilcox, William U. Primrose, +1 author R. A. John Challiss
• Published in Trends in pharmacological sciences 1998

Receptor-mediated activation of phospholipase C to generate inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] is a ubiquitous signalling pathway in mammalian systems. A family of three IP3 receptor subtype monomers form functional tetramers, which act as effectors for Ins(1,4,5)P3, providing a ligand-gated channel that allows Ca2+ ions to move between cellular compartments. As IP3 receptors are located principally, although not exclusively, in the endoplasmic reticular membrane, Ins(1,4,5)P3 is… CONTINUE READING

Save to Library

Create Alert

Cite

View Paper