New developments in quantitative polymerase chain reaction applied to control the quality of heparins.

@article{Auguste2011NewDI,
  title={New developments in quantitative polymerase chain reaction applied to control the quality of heparins.},
  author={C{\'e}cile Auguste and St{\'e}phanie Dereux and C{\'e}line Martinez and Pascal Anger},
  journal={Analytical and bioanalytical chemistry},
  year={2011},
  volume={399 2},
  pages={747-55}
}
Heparin is a widely used intravenous anticoagulant comprised of a very complex mixture of glucosaminoglycan chains, mainly derived from porcine intestinal mucosa. Recent contamination of heparin with oversulfated (OS) chondroitin sulfate resulted in a significant number of deaths, triggering a rapid revision of product monographs and the introduction of new analytical methods to limit as far as possible the chances of another occurrence of such a phenomenon. The distribution of heparin… CONTINUE READING