New developments in natural products-based anti-AIDS research.

  title={New developments in natural products-based anti-AIDS research.},
  author={Donglei Yu and Susan Lynne Morris-Natschke and Kuo-Hsiung Lee},
  journal={Medicinal research reviews},
  volume={27 1},
This review discusses anti-HIV natural products from several compound classes, including terpenoids, coumarins, alkaloids, polyphenols, tannins, and flavonoids. Natural products can provide novel anti-AIDS chemotherapeutic leads that are structurally unique or have new mechanisms of action. The drug discovery and development process proceeds from bioactivity-directed isolation and identification of a promising lead natural product, followed by rational design-based structural modification and… CONTINUE READING

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