New developments in massive transfusion in trauma

@article{Greer2010NewDI,
  title={New developments in massive transfusion in trauma},
  author={S. Greer and Kurt K. Rhynhart and Rajan Gupta and H. Corwin},
  journal={Current Opinion in Anaesthesiology},
  year={2010},
  volume={23},
  pages={246–250}
}
Purpose of review Trauma patients requiring massive transfusion represent a population at high risk for potentially preventable death. This review describes recent advances in the early recognition and treatment of the coagulopathy of trauma, as well as ongoing work to define optimal resuscitation strategies. Recent findings Damage control resuscitation involves the rapid correction of hypothermia and acidosis, direct treatment of coagulopathy, and early transfusion in trauma patients. Recent… Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Definitive management of the exsanguinating patient challenges providers in multiple specialties. Significant hemorrhage may be encountered in a variety of circumstances including elective orExpand
Determinants of mortality in trauma patients following massive blood transfusion
TLDR
Overall mortality among the MBT patients was comparable with the studies in the literature, and Prospective studies are required to further validate the determinants of mortality and establish guidelines for MBT. Expand
C URRENT OPINION Perioperative coagulation management in the intensive care unit
TLDR
Therapeutic prohemostatic pharmacologic approaches need to be considered in managing coagulopathy in the ICU setting because of multiple factors including anticoagulants, dilution, fibrinolysis, and factor consumption. Expand
Update and New Developments in the Management of the Exsanguinating Patient
TLDR
The challenges of dealing with the “lethal triad” will be discussed, as will the various aspects of damage control and hemostatic resuscitation, and the latest literature and controversy regarding massive transfusions and massive transfusion protocols will be elucidated with inclusion of data from recent military experiences. Expand
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TLDR
The best evidence related to transfusion-related outcome involves titrating transfusion requirements to parameters of severity of illness rather than arbitrarily defined Hb levels. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Patients who were hypothermic and acidotic developed clinically significant bleeding despite adequate blood, plasma, and platelet replacement and may be critical in preventing or correcting coagulopathy in the patient receiving massive transfusion. Expand
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