New developments in malaria diagnostics: monoclonal antibodies against Plasmodium dihydrofolate reductase-thymidylate synthase, heme detoxification protein and glutamate rich protein.

@article{Kattenberg2012NewDI,
  title={New developments in malaria diagnostics: monoclonal antibodies against Plasmodium dihydrofolate reductase-thymidylate synthase, heme detoxification protein and glutamate rich protein.},
  author={Johanna Helena Kattenberg and Inge A J Versteeg and Stephanie J Migchelsen and Iveth J. Gonz{\'a}lez and Mark D. Perkins and Petronella F Mens and Henk D. H. F. Schallig},
  journal={mAbs},
  year={2012},
  volume={4 1},
  pages={120-6}
}
Currently available rapid diagnostic tests (RDTs) for malaria show large variation in sensitivity and specificity, and there are concerns about their stability under field conditions. To improve current RDTs, monoclonal antibodies (mAbs) for novel malaria antigens have been developed and screened for their possible use in new diagnostic tests. Three antigens, glutamate rich protein (GLURP), dihydrofolate reductase-thymidylate synthase (DHFR-TS) and heme detoxification protein (HDP), were… CONTINUE READING

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