New definitions of pre-extensively and extensively drug-resistant tuberculosis: update from the World Health Organization

  title={New definitions of pre-extensively and extensively drug-resistant tuberculosis: update from the World Health Organization},
  author={Kerri Viney and Nguyen Nhat Linh and Medea Gegia and Matteo Zignol and Philippe Glaziou and Nazir Ahmed Ismail and Tereza Kasaeva and Fuad Mirzayev},
  journal={European Respiratory Journal},
Multidrug-resistant tuberculosis (MDR-TB), defined as Mycobacterium tuberculosis with resistance to at least isoniazid and rifampicin [1], emerged as a threat to tuberculosis (TB) control worldwide in the 1990s [2]. This form of TB required the use of second-line drugs that were less effective, more toxic and costlier than first-line isoniazid- and rifampicin-based regimens. MDR-TB was one of the first infectious conditions to alert national authorities worldwide to the importance of… 

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