New cytotoxic sulfated saponins from the starfish Certonardoa semiregularis.

@article{Wang2005NewCS,
  title={New cytotoxic sulfated saponins from the starfish Certonardoa semiregularis.},
  author={Weihong Wang and Hyojin Jang and Jongki Hong and Chong-Ok Lee and S Bae and Sook Shin and Jee H Jung},
  journal={Archives of pharmacal research},
  year={2005},
  volume={28 3},
  pages={285-9}
}
Two new sulfated saponins designated as certonardosides P2 and I3 (1 and 2) were isolated from the brine shrimp active fraction of the MeOH extract of the starfish Certonardoa semiregularis. The structures were determined on the basis of spectral analysis. Compounds 1 and 2 were tested for cytotoxicity against five human tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15), and compound 1 displayed significant cytotoxicity against the SK-MEL-2 skin cancer cell.