New cytotoxic spongian-class rearranged diterpenes from a marine sponge


Chemical investigation of an Okinawan marine sponge resulted in the isolation of two new spongian-class diterpenes 1 and 2 together with two known compounds, chromodorolide B (3) and chromodorolide C (4). Compound 1, named chromodorolide D, is an example of a diterpenoid with a highly rearranged chromodorane carbon skeleton, while compound 2 retains the open side chains. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis and chemical conversion. Compounds 1–4 exhibited significant cytotoxicity against NBT-T2 rat bladder epithelial cells.

DOI: 10.1007/s10600-012-0262-9

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@article{Uddin2012NewCS, title={New cytotoxic spongian-class rearranged diterpenes from a marine sponge}, author={Mohammad Helal Uddin and Mohammed Kamrul Hossain and Meher Nigar and Michael Chandro Roy and J. Tanaka}, journal={Chemistry of Natural Compounds}, year={2012}, volume={48}, pages={412-415} }