New cytotoxic sesquiterpene lactones from Warionia saharae.

  title={New cytotoxic sesquiterpene lactones from Warionia saharae.},
  author={Fatima Hilmi and Otto Sticher and Joerg Heilmann},
  journal={Planta medica},
  volume={69 5},
Cytotoxicity-guided fractionation of the methanol soluble part of the dichloromethane extract of the leaves of Warionia saharae led to the isolation of the two new guaianolide-type sesquiterpene lactones, 5 alpha H-3 beta,4 beta-epoxy-14-oxo-guaia-1(10),11(13)-dien-6 alpha,12-olide (1), 5 alpha H-2 beta,4 beta-epoxy-3 alpha-hydroxy-guaia-1(10),11(13)-dien-6 alpha,12-olide (6), and the new eudesmane type sesquiterpene 1 beta,6 alpha-dihydroxycostic acid ( 4). In addition, the known sesquiterpene… CONTINUE READING