New cytotoxic metabolites from a deep-sea-derived fungus, Phialocephala sp., strain FL30r.

@article{Li2011NewCM,
  title={New cytotoxic metabolites from a deep-sea-derived fungus, Phialocephala sp., strain FL30r.},
  author={Dehai Li and Sheng-xin Cai and Tian-Jiao Zhu and Feng-ping Wang and Xiang Li Xiao and Qian-qun Gu},
  journal={Chemistry & biodiversity},
  year={2011},
  volume={8 5},
  pages={895-901}
}
Two new sorbicillinoids, 1 and 2, together with a novel benzofuranone derivative named phialofurone (3), were isolated from a deep-sea sediment-derived fungus, Phialocephala sp. Their structures were established on the basis of spectroscopic data. All compounds displayed cytotoxic effects against P388 (IC(50) values of 11.5±1.4, 0.1±0.1, and 0.2±0.01 μM, resp.) and K562 (IC(50) values of 22.9±0.8, 4.8±0.3 and 22.4±0.9 μM, resp.) cell lines. 

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