New control of mitochondrial membrane potential and ROS formation--a hypothesis.

@article{Lee2001NewCO,
  title={New control of mitochondrial membrane potential and ROS formation--a hypothesis.},
  author={Icksoo Lee and Elisabeth Bender and Shane Arnold and Bernhard Kadenbach},
  journal={Biological chemistry},
  year={2001},
  volume={382 12},
  pages={1629-36}
}
A new control of mitochondrial membrane potential delta(psi)m and formation of reactive oxygen species (ROS) is presented, based on allosteric ATP-inhibition of cytochrome c oxidase at high intramitochondrial ATP/ADP ratios. Since the rate of ATP synthesis by the ATP synthase is already maximal at low membrane potentials (100-120 mV), the ATP/ADP ratio will also be maximal at this delta(psi)m (at constant rate of ATP consumption). Therefore the control of respiration by the ATP/ADP-ratio keeps… CONTINUE READING