New conjugates of muramyl dipeptide and nor-muramyl dipeptide linked to tuftsin and retro-tuftsin derivatives significantly influence their biological activity.

Abstract

The synthesis and biological activity of new conjugates of muramyl dipeptide (MDP) and nor-muramyl dipeptide (nor-MDP) with tuftsin and retro-tuftsin derivatives containing isopeptide bond between ε-amino group of lysine and carboxyl group of simple amino acids such as Ala, Gly and Val are presented. We presumed, based on the cytokine profile, that the… (More)

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Cite this paper

@article{Dzierzbicka2012NewCO, title={New conjugates of muramyl dipeptide and nor-muramyl dipeptide linked to tuftsin and retro-tuftsin derivatives significantly influence their biological activity.}, author={Krystyna Dzierzbicka and Anna Wardowska and Małgorzata Rogalska and Piotr Trzonkowski}, journal={Pharmacological reports : PR}, year={2012}, volume={64 1}, pages={217-23} }