New conjugated polymers for photoinduced unwinding of DNA supercoiling and gene regulation.


Three cationic polythiophene derivatives (P1, P2, P3) were synthesized and characterized. Under white light irradiation (400-800 nm), they sensitize oxygen molecule in the surrounding to generate reactive oxygen species (ROS) that can efficiently unwind the supercoiled DNA in vitro. Further study shows that this relaxation of the DNA supercoiling results in… (More)
DOI: 10.1021/am300464m

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