New concepts on progressive multiple sclerosis.

  title={New concepts on progressive multiple sclerosis.},
  author={Hans Lassmann},
  journal={Current neurology and neuroscience reports},
  volume={7 3},
  • Hans Lassmann
  • Published 2007 in Current neurology and neuroscience reports
Multiple sclerosis is generally regarded as a putative autoimmune disease of the central nervous system in which a chronic T-cell-mediated inflammation leads to focal plaques of demyelination in the white matter of the central nervous system. This plaque-centered view of the disease, however, fails to explain clinical deterioration of the patients when they have reached the progressive stage of the disease. It was thus postulated during the past few years that besides inflammation there is a… CONTINUE READING