New concepts of the neuroendocrine regulation of gonadotropin surges in rats.

@article{Levine1997NewCO,
  title={New concepts of the neuroendocrine regulation of gonadotropin surges in rats.},
  author={John E Levine},
  journal={Biology of reproduction},
  year={1997},
  volume={56 2},
  pages={293-302}
}
In species that ovulate spontaneously, two key events mediate the stimulation of preovulatory gonadotropin surges: 1) neurosecretion of a preovulatory LHRH surge and 2) an acute increase in responsiveness of the pituitary gland to the LHRH neurosecretory trigger. These processes, in turn, depend upon both the positive feedback actions of preovulatory estrogen secretions and specific neural signals for initiation of the surge. In female rats, the neural signals for the surge are principally… CONTINUE READING
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