New concepts in breast cancer metastasis: tumor initiating cells and the microenvironment

@article{Sleeman2007NewCI,
  title={New concepts in breast cancer metastasis: tumor initiating cells and the microenvironment},
  author={Jonathan P Sleeman and Natascha Cremers},
  journal={Clinical & Experimental Metastasis},
  year={2007},
  volume={24},
  pages={707-715}
}
The currently prevailing ideas that set out to explain the process of metastasis are largely based on observations made on the total tumor cell population, and often focus on tumor-intrinsic properties. The clinical observation that particular tumor types show a predilection to metastasize to particular organs has been understood in terms of Paget’s “Seed and Soil” hypothesis, but a definition of the molecular basis for the “Seed and Soil” hypothesis is at best only partial. Recent ideas about… CONTINUE READING

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