New concepts in benzodiazepine therapy: Rebound anxiety and new indications for the more potent benzodiazepines

@article{Chouinard1983NewCI,
  title={New concepts in benzodiazepine therapy: Rebound anxiety and new indications for the more potent benzodiazepines},
  author={G. Chouinard and A. Labont{\'e} and R. Fontaine and L. Annable},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1983},
  volume={7},
  pages={669-673}
}
Abrupt withdrawal of benzodiazepine treatment in generalized anxiety patients was found to induce a rebound anxiety state in addition to minor physical symptoms. Controlled clinical trials suggest that the newer high potency benzodiazepines (alprazolam, clonazepam and bromazepam) have novel psychiatric indications and greater anxiolytic effect than the classical benzodiazepines. Alprazolam, a triazolobenzodiazepine, was superior to placebo in the treatment of panic disorder, for which medium or… Expand
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