New concepts in atrial fibrillation: neural mechanisms and calcium dynamics.

@article{Chou2009NewCI,
  title={New concepts in atrial fibrillation: neural mechanisms and calcium dynamics.},
  author={Chung-Chuan Chou and Peng-Sheng Chen},
  journal={Cardiology clinics},
  year={2009},
  volume={27 1},
  pages={35-43, viii}
}
Atrial fibrillation (AF) is a complex arrhythmia with multiple possible mechanisms. It requires a trigger for initiation and a favorable substrate for maintenance. Pulmonary vein myocardial sleeves have the potential to generate spontaneous activity, and this arrhythmogenic activity is surfaced by modulation of intracellular calcium dynamics. Direct autonomic nerve recordings in canine models show that simultaneous sympathovagal discharges are the most common triggers of paroxysmal atrial… CONTINUE READING

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