New concepts in asthma: clinical phenotypes and pathophysiological mechanisms.

  title={New concepts in asthma: clinical phenotypes and pathophysiological mechanisms.},
  author={Andreas Rembert Koczulla and Claus F Vogelmeier and Holger Garn and Harald Renz},
  journal={Drug discovery today},
  volume={22 2},
Asthma is among the most common chronic inflammatory diseases worldwide. Recent evidence indicates that the pathogenesis shows a high degree of heterogeneity. Patient subsets have been identified that exhibit different cellular and molecular patterns of dysregulation. A prominent example is eosinophilic Th2-driven asthma. These unique and molecular patterns are termed endotypes. Characterization of endotypes has broad implications for therapeutic interventions. Although ∼80% of asthmatic… CONTINUE READING
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