New clues about vitamin D functions in the nervous system

  title={New clues about vitamin D functions in the nervous system},
  author={E. Garcion and N. Wion-Barbot and C. Montero-Menei and F. Berger and Didier Wion},
  journal={Trends in Endocrinology & Metabolism},
  • E. Garcion, N. Wion-Barbot, +2 authors Didier Wion
  • Published 2002
  • Biology, Medicine
  • Trends in Endocrinology & Metabolism
  • Accumulating data have provided evidence that 1 alpha,25 dihydroxyvitamin D(3) [1,25-(OH)(2)D(3)] is involved in brain function. Thus, the nuclear receptor for 1,25-(OH)(2)D(3) has been localized in neurons and glial cells. Genes encoding the enzymes involved in the metabolism of this hormone are also expressed in brain cells. The reported biological effects of 1,25-(OH)(2)D(3) in the nervous system include the biosynthesis of neurotrophic factors and at least one enzyme involved in… CONTINUE READING
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