New classification and update on the quinolone antibiotics.

@article{King2000NewCA,
  title={New classification and update on the quinolone antibiotics.},
  author={Dana E King and Robb Malone and Scarlett Lilley},
  journal={American family physician},
  year={2000},
  volume={61 9},
  pages={2741-8}
}
The newer fluoroquinolones have broad-spectrum bactericidal activity, excellent oral bioavailability, good tissue penetration and favorable safety and tolerability profiles. A new four-generation classification of the quinolone drugs takes into account the expanded antimicrobial spectrum of the more recently introduced fluoroquinolones and their clinical indications. First-generation drugs (e.g., nalidixic acid) achieve minimal serum levels. Second-generation quinolones (e.g., ciprofloxacin… CONTINUE READING

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