New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease.

@article{Lashuel2002NewCO,
  title={New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease.},
  author={Hilal A Lashuel and Dean M. Hartley and David Balakhaneh and Aneel K. Aggarwal and Saul Teichberg and David J. E. Callaway},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 45},
  pages={
          42881-90
        }
}
The amyloid hypothesis suggests that the process of amyloid-beta protein (Abeta) fibrillogenesis is responsible for triggering a cascade of physiological events that contribute directly to the initiation and progression of Alzheimer's disease. Consequently, preventing this process might provide a viable therapeutic strategy for slowing and/or preventing the progression of this devastating disease. A promising strategy to achieve prevention of this disease is to discover compounds that inhibit… CONTINUE READING

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1 Excerpt

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