New class of hallucinogens: GABA‐enhancing agents

@article{Hollister1990NewCO,
  title={New class of hallucinogens: GABA‐enhancing agents},
  author={Leo E. Hollister},
  journal={Drug Development Research},
  year={1990},
  volume={21}
}
  • L. Hollister
  • Published 1990
  • Psychology, Medicine, Biology
  • Drug Development Research
Hallucinogenic drugs are of interest to psychiatrists as possible models of schizophrenia. Possibly some of the mechanisms by which these drugs elicit altered mental states might lead to a better understanding of schizophrenia. GABA‐enhancing drugs, such as muscimol and CI‐966, produce mental states that differ in various ways from those of other hallucinogens. The mechanism of action also differs from the others, which may be mediated by receptors for serotonin (LSD), acetylcholine… 
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References

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Initial human safety and tolerance study of a GABA uptake inhibitor, Cl‐966: Potential role of GABA as a mediator in the pathogenesis of schizophrenia and mania
TLDR
It is suggested that GABA may modulate memory and dopaminergic pathways responsible for posture and muscle control and may be a potentially important mediator in the pathogenesis of schizophrenia and mania.