New class of glutamate agonist structurally related to ibotenic acid

@article{KrogsgaardLarsen1980NewCO,
  title={New class of glutamate agonist structurally related to ibotenic acid},
  author={Povl Krogsgaard-Larsen and Tage Honor{\'e} and Jan J. Hansen and David R. Curtis and David Lodge},
  journal={Nature},
  year={1980},
  volume={284},
  pages={64-66}
}
L-Glutamic acid (Glu) and L-aspartic acid (Asp) are putative excitatory transmitters in the mammalian central nervous system (CNS)1–3. Receptors at Glu- and Asp-mediated synapses are presumably different4,5, and a prerequisite for the identification and characterisation of such sites is the availability of specific antagonists and agonists. Among various potential Glu and Asp antagonists3–6 Glu diethyl ester (GDEE)7–9 and (D)-α-aminoadipic acid (α-AA)9–13 show some selectivity, the latter… CONTINUE READING

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