New class of competitive inhibitor of bacterial histidine kinases.

@article{Gilmour2005NewCO,
  title={New class of competitive inhibitor of bacterial histidine kinases.},
  author={Raymond Gilmour and J Estelle Foster and Qin Sheng and Jonathan R McClain and Anna Riley and Pei-ming Sun and Wai-Leung Ng and De-yue Yan and Thalia I. Nicas and Kenneth Henry and Malcolm E Winkler},
  journal={Journal of bacteriology},
  year={2005},
  volume={187 23},
  pages={
          8196-200
        }
}
Bacterial histidine kinases have been proposed as targets for the discovery of new antibiotics, yet few specific inhibitors of bacterial histidine kinases have been reported. We report here a novel thienopyridine (TEP) compound that inhibits bacterial histidine kinases competitively with respect to ATP but does not comparably inhibit mammalian serine/threonine kinases. Although it partitions into membranes and does not inhibit the growth of bacterial or mammalian cells, TEP could serve as a… CONTINUE READING

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