New chiral and isomeric cyclopropyl ketoxime propanolamine derivatives with potent beta-adrenergic blocking properties.

@article{Bouzoubaa1985NewCA,
  title={New chiral and isomeric cyclopropyl ketoxime propanolamine derivatives with potent beta-adrenergic blocking properties.},
  author={M. Bouzoubaa and G. Leclerc and S. Rakhit and G. Andermann},
  journal={Journal of medicinal chemistry},
  year={1985},
  volume={28 7},
  pages={
          896-900
        }
}
The synthesis of R-(+) and S-(-) isomers of O-[3-tert-butylamino)-2-hydroxypropyl] cyclopropyl methyl ketone oxime (falintolol) is described. The syn and anti isomers of falintolol were obtained in two different ways from cyclopropyl methyl ketoxime or from falintolol. For comparison purposes, the enantiomers of the dicyclopropyl ketone oxime derivatives were also prepared. Structure-activity relationships are described. 
21 Citations
...
1
2
3
...