New chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase from Wolbachia endobacteria.

Abstract

Substituted benzimidazoles of the wALADin1-family have recently been identified as a new class of species-selective inhibitors of delta-aminolevulinic acid dehydratase (ALAD) from Wolbachia endobacteria of parasitic filarial worms. Due to its Wolbachia-dependent antifilarial activity, wALADin1 is a starting point for the development of new drugs against filarial nematodes. We now present several other chemotypes of ALAD inhibitors that have been identified based upon their molecular similarity to wALADin1. A tricyclic quinoline derivative (wALADin2) with a different inhibitory mechanism and improved inhibitory potency and selectivity may represent an improved drug lead candidate.

DOI: 10.1016/j.bmcl.2013.08.052

Cite this paper

@article{Lentz2013NewCF, title={New chemotypes for wALADin1-like inhibitors of delta-aminolevulinic acid dehydratase from Wolbachia endobacteria.}, author={Christian S Lentz and Dagmar Stumpfe and J{\"{u}rgen Bajorath and Michael Famulok and Achim Hoerauf and Kenneth M. Pfarr}, journal={Bioorganic & medicinal chemistry letters}, year={2013}, volume={23 20}, pages={5558-62} }