New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.

@article{lvarez2014NewCA,
  title={New chemotypes as Trypanosoma cruzi triosephosphate isomerase inhibitors: a deeper insight into the mechanism of inhibition.},
  author={Guzm{\'a}n {\'A}lvarez and Jennyfer Mart{\'i}nez and Beatriz Aguirre-L{\'o}pez and Nallely Cabrera and Leticia P{\'e}rez-D{\'i}az and Marietta Tuena de G{\'o}mez-Puyou and Armando G{\'o}mez-Puyou and Ruy Perez-Montfort and Beatriz Garat and Alicia Merlino and Mercedes Gonz{\'a}lez and Hugo Cerecetto},
  journal={Journal of enzyme inhibition and medicinal chemistry},
  year={2014},
  volume={29 2},
  pages={198-204}
}
CONTEXT Triosephosphate isomerase (TIM) is a ubiquitous enzyme that has been targeted for the discovery of new small molecular weight compounds used against Trypanosoma cruzi, the causative agent of Chagas disease. We have identified phenazine and 1,2,6-thiadiazine chemotypes as novel inhibitors of TIM from T. cruzi (TcTIM). OBJECTIVE Study the mechanism of TcTIM inhibition by a phenazine derivative and by a 1,2,6-thiadiazine derivative. METHODS We performed biochemical and theoretical… CONTINUE READING
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