New chemotherapeutic strategies against malaria, leishmaniasis and trypanosomiases.

@article{Zucca2013NewCS,
  title={New chemotherapeutic strategies against malaria, leishmaniasis and trypanosomiases.},
  author={Mariagrazia Zucca and Sara Scutera and Dianella Savoia},
  journal={Current medicinal chemistry},
  year={2013},
  volume={20 4},
  pages={
          502-26
        }
}
Due to the persistent lack of suitable vaccines, chemotherapy remains the only option for the treatment of patients infected by protozoan parasites. However, most available antiparasitic drugs have serious disadvantages, ranging from high cost and poor compliance to high toxicity and rapid induction of resistance. In recent decades basic research laboratories identified a considerable number of promising new molecules, but their development has not been pursued in depth by pharmaceutical firms… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Vaccines for the prevention of infections in adults: an opinion paper on the situation in Spain

  • Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia
  • 2019

An overview on Leishmania vaccines: A narrative review article

  • Veterinary research forum : an international quarterly journal
  • 2015

Recent updates and perspectives on leishmaniasis.

  • Journal of infection in developing countries
  • 2015
VIEW 1 EXCERPT
CITES BACKGROUND

The antimalarial drug proguanil is an antagonist at 5-HT3 receptors.

  • The Journal of pharmacology and experimental therapeutics
  • 2014
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 235 REFERENCES

Efficacy of miltefosine in the treatment of visceral leishmaniasis in India after a decade of use.

  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2012
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Global phenotypic screening for antimalarials.

  • Chemistry & biology
  • 2012
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

MK-4815, a potential new oral agent for treatment of malaria.

  • Antimicrobial agents and chemotherapy
  • 2012
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Modern Malaria Chemoprophylaxis

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL