New checkpoints in cancer immunotherapy.

@article{Ni2017NewCI,
  title={New checkpoints in cancer immunotherapy.},
  author={L Ni and Chen Dong},
  journal={Immunological reviews},
  year={2017},
  volume={276 1},
  pages={52-65}
}
Immune responses must be fine-tuned to allow effective clearance of invading pathogens, while maintain tolerance to self-antigens. T cells are the major effector cells for fighting and killing tumor cells. Immune checkpoints play a pivotal role in T cell activation, and determine the functional outcome of T cell receptor (TCR) signaling. The blockade of immune checkpoints CTLA-4 and PD-1 has already been one of the most successful cancer immunotherapies. In this review, we will focus on three… CONTINUE READING
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