New channel blocker BIIA388CL blocks delayed rectifier, but not A-type potassium current in central neurons

  title={New channel blocker BIIA388CL blocks delayed rectifier, but not A-type potassium current in central neurons},
  author={Oleg Krishtal and Yu. V. Kirichok and Timur Tsintsadze and Natasha A. Lozovaya and Walter Loesel and Dietrich Arndts},
Mechanism of carvedilol‐induced block of delayed rectifier K+ current in the NG108‐15 neuronal cell line
It is shown that in addition to being an antioxidative agent, carvedilol can block delayed rectifying K+ channel of neurons in an open‐ and state‐dependent manner.
Effects of sodium metabisulfite on potassium currents in acutely isolated CA1 pyramidal neurons of rat hippocampus.
  • Z. Meng, A. Nie
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2005
Effects of carvedilol on delayed rectifier and transient inactivating potassium currents in rat hippocampal CA1 neurons
The aims of the present study were to investigate the mechanism(s) underlying the protective effect of carvedilol against neural damage and to establish the carrier and removal status of canine coronavirus in mice.


LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and cortical neurons in culture.
It is concluded that LOE 908 is a K+ channel blocker with selectivity for delayed outward rectifying K+ channels in undifferentiated cells and in rat cortical neurons in primary culture.
Enhancement of Outward Potassium Current May Participate in β-Amyloid Peptide-Induced Cortical Neuronal Death
The intriguing possibility that manipulations aimed at reducing outward K+ current may provide an approach to reducing neuronal degeneration in patients with Alzheimer's disease is raised.
A discriminant block among K+ channel types by phenytoin in neuroblastoma cells
The results confirmed the phenytoin effect on K+ currents and suggest that the drug may be considered a selective blocker of delayed rectifier K+ channels, while the unitary current amplitude was unaffected in all three types of channels.
Physiology and pharmacology of epileptiform activity induced by 4-aminopyridine in rat hippocampal slices.
Small, nonsynchronous EPSPs played an important role in the generation of 4-AP-induced epileptiform activity and were positively correlated with the frequency of occurrence of synchronous bursts, suggesting that both inhibitory and excitatory conductances were involved in its generation.
TEA elicits two distinct potentiations of synaptic transmission in the CA1 region of the hippocampal slice
  • E. Hanse, B. Gustafsson
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1994
The relation between TEA-induced potentiation and NMDA receptor- dependent long-term potentiation (LTP) was investigated in the CA1 region of the hippocampal slice using extracellular recordings and picrotoxin to block GABAA-mediated inhibition.
Comparison of voltage-dependent potassium currents in rat pyramidal neurons acutely isolated from hippocampal regions CA1 and CA3.
In CA1 as well as in CA3 cells, the kinetic and pharmacological properties of IA and IK remained stable during postnatal development, however, the contribution of IAand IK to the whole cell current varied with age.
Functional and Molecular Differences between Voltage-Gated K+ Channels of Fast-Spiking Interneurons and Pyramidal Neurons of Rat Hippocampus
The results indicate that the differential expression of Kv3 and Kv4 subunits shapes the action potential phenotypes of principal neurons and interneurons in the cortex.