New channel blocker BIIA388CL blocks delayed rectifier, but not A-type potassium current in central neurons

@article{Krishtal2001NewCB,
  title={New channel blocker BIIA388CL blocks delayed rectifier, but not A-type potassium current in central neurons},
  author={O. Krishtal and Y. Kirichok and T. Tsintsadze and N. Lozovaya and D. Arndts},
  journal={Neuropharmacology},
  year={2001},
  volume={40},
  pages={233-241}
}
A new substance (R,S)-(3,4-dihydro-6,7-dimethoxyisoquinoline-1-yl)-2-cyclohexyl-N-(3,3-diphenylpropyl)-acetamide hydrochloride (BIIA388Cl), which demonstrates neuroprotective properties in animal models, was examined for its action on K(+) currents in acutely isolated rat hippocampal neurons using the patch-clamp/concentration clamp techniques in the whole-cell configuration. The delayed rectifier K(+)-current (I(DR)) was strongly inhibited by externally applied BIIA388Cl, while the transient A… Expand
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