New cell lines from mouse epiblast share defining features with human embryonic stem cells

@article{Tesar2007NewCL,
  title={New cell lines from mouse epiblast share defining features with human embryonic stem cells},
  author={Paul J Tesar and Josh G. Chenoweth and Frances Anne Brook and Timothy J. Davies and Edward P. Evans and David L. Mack and Richard L. Gardner and R D G Mckay},
  journal={Nature},
  year={2007},
  volume={448},
  pages={196-199}
}
The application of human embryonic stem (ES) cells in medicine and biology has an inherent reliance on understanding the starting cell population. Human ES cells differ from mouse ES cells and the specific embryonic origin of both cell types is unclear. Previous work suggested that mouse ES cells could only be obtained from the embryo before implantation in the uterus. Here we show that cell lines can be derived from the epiblast, a tissue of the post-implantation embryo that generates the… CONTINUE READING
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