New candidate tumor-suppressor gene KLF6 and its splice variant KLF6 SV2 counterbalancing expression in primary hepatocarcinoma.

@article{Zhenzhen2012NewCT,
  title={New candidate tumor-suppressor gene KLF6 and its splice variant KLF6 SV2 counterbalancing expression in primary hepatocarcinoma.},
  author={Zhou Zhenzhen and Tian De'an and Xia Limin and Y. -J. Wei and Luo Min},
  journal={Hepato-gastroenterology},
  year={2012},
  volume={59 114},
  pages={473-6}
}
BACKGROUND/AIMS This study aimed to detect the expression of newly discovered zinc finger transcriptional factor KLF6 and its splice variant KLF6 SV2 in primary hepatocarcinoma (PHC) tissues and hepatoma cell strains, and to evaluate their clinicopathologic relationship with PHC. METHODOLOGY Wild-type KLF6 and KLF6 SV2 mRNA expression was determined by RTPCR in 27 cases of PHC tissues and cell strains of HepG2, SMMC7721 and LO2. Western blotting and immunohistochemical staining were adopted… CONTINUE READING

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