New bradykinin analogs in contraction of rat uterus.

  title={New bradykinin analogs in contraction of rat uterus.},
  author={Henryk I. Trzeciak and Wojciech Kozik and Samed Melhem and Angelika Kania and Dariusz Dobrowolski and Adam Prahl and Izabela Derdowska and B. Lammek},
  volume={21 6},
In this study, we evaluated 20 of our previously synthesized peptides on isolated rat uterus by Holton's procedure with minor modifications, and compared their activity with that assessed previously by their ability to inhibit vasodepressor response to exogenous bradykinin (BK) in conscious rats. We used [D-Arg(0), Hyp(3), Thi(5, 8), (D-Phe)(7)]BK, the B(2) antagonist of Vavrek and Stewart as a model when designing our analogs. We observed that, in the case of the rat uterus test, the activity… CONTINUE READING

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