New blends of hydroxypropylmethylcellulose and Gelucire 44/14: physical property and controlled release of drugs with different solubility

Abstract

New blends of hydroxypropylmethylcellulose (HPMC, 4000 cps) and Gelucire®44/14 (GE) were utilized to modulate the solubility and release rate of poorly water-soluble drug in a controlled manner. HPMC was used as sustained release polymer while GE was blended as a solubilizing carrier. The binary blends of HPMC and GE with proportional ratios (0, 25, 50, 70… (More)
DOI: 10.1007/s40005-017-0322-z

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Cite this paper

@article{Lee2017NewBO, title={New blends of hydroxypropylmethylcellulose and Gelucire 44/14: physical property and controlled release of drugs with different solubility}, author={Kyung-Ho Lee and Chulhun Park and Giwon Oh and Jun-Bom Park and Beom-Jin Lee}, journal={Journal of Pharmaceutical Investigation}, year={2017}, pages={1-9} }