New bis-aminomercaptotriazoles and bis-triazolothiadiazoles as possible anticancer agents.

@article{Holla2002NewBA,
  title={New bis-aminomercaptotriazoles and bis-triazolothiadiazoles as possible anticancer agents.},
  author={Bantwal Shivarama Holla and K Narayana Poojary and B Sooryanarayana Rao and M. K. Shivananda},
  journal={European journal of medicinal chemistry},
  year={2002},
  volume={37 6},
  pages={511-7}
}
A series of bis-phenoxyacetic acids 2 were prepared starting from corresponding unsubstituted/substituted 1,4-quinols 1. The fusion of bis-phenoxyacetic acids 2 with thiocarbohydrazide gave the corresponding bis-[4-amino-5-mercapto-1,2,4-triazol-3-yl-methyleneoxy]phenylenes (3) in a one pot reaction. The reaction of bis-triazoles 3 with various reagents afforded N-bridged heterocycles 4-6 in good yields. The newly synthesised compounds were screened for their anticancer activity against a panel… CONTINUE READING

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