New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy.

@article{Geluk2012NewBW,
  title={New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy.},
  author={Annemieke Geluk and Kidist Bobosha and Jolien J. van der Ploeg-van Schip and John S Spencer and S. Munawara Banu and Marcia Val{\'e}ria B S Martins and S. -T. Cho and Kees L M C Franken and Hee Jin Kim and Yonas Bekele and Mohammad Khaja Mafij Uddin and Sheikh Abdul Hadi and Abraham Aseffa and Maria Cristina Vidal Pessolani and Geraldo Moura Batista Pereira and Hazel M. Dockrell and Tom H. M. Ottenhoff},
  journal={Journal of immunology},
  year={2012},
  volume={188 10},
  pages={4782-91}
}
Leprosy is not eradicable with currently available diagnostics or interventions, as evidenced by its stable incidence. Early diagnosis of Mycobacterium leprae infection should therefore be emphasized in leprosy research. It remains challenging to develop tests based on immunological biomarkers that distinguish individuals controlling bacterial replication from those developing disease. To identify biomarkers for field-applicable diagnostics, we determined cytokines/chemokines induced by M… CONTINUE READING

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