New biomarker evidence of oxidative DNA damage in patients with non-insulin-dependent diabetes mellitus.

@article{Leinonen1997NewBE,
  title={New biomarker evidence of oxidative DNA damage in patients with non-insulin-dependent diabetes mellitus.},
  author={Jari Leinonen and Terho Lehtim{\"a}ki and Shinya Toyokuni and Kenta Okada and Tsutomu Tanaka and Hiroshi Hiai and Hidenori Ochi and Pekka Laippala and Vappu Marianna Rantalaiho and Ole Wirta and Amos Pasternack and Hannu Alho},
  journal={FEBS letters},
  year={1997},
  volume={417 1},
  pages={150-2}
}
Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) has been reported to serve as a sensitive biomarker of oxidative DNA damage and also of oxidative stress. We have investigated oxidative DNA damage in patients with non-insulin-dependent diabetes mellitus (NIDDM) by urinary 8-OHdG assessments. We determined the total urinary excretion of 8-OHdG from 24 h urine samples of 81 NIDDM patients 9 years after the initial diagnosis and of 100 non-diabetic control subjects matched for age and gender. The… CONTINUE READING
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