New biologically active pregnan-21-oic acid esters.

@article{Laurent1975NewBA,
  title={New biologically active pregnan-21-oic acid esters.},
  author={Henry Laurent and Erich Prof Dr Gerhards and Rudolf Prof. Dr. Wiechert},
  journal={Journal of steroid biochemistry},
  year={1975},
  volume={6 3-4},
  pages={
          185-92
        }
}
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Triamcinolone acetonide 21-oic acid methyl ester: a potent local antiinflammatory steroid without detectable systemic effects.
TLDR
The synthesis of esters of the 21-oic acid of triamcinolone acetonide and the high affinity of the ester for human glucocorticoid receptors suggest that TAme may eventually be useful clinically, as a locum scopolamine-like substance.
Binding of glucocorticoid 21-oic acids and esters to molybdate-stabilized hepatic receptors.
Synthesis of a new anti-inflammatory steroidal acid ester: methyl 11 beta-hydroxy-3,20-dioxo-1,4-pregnadien-21-oate.
TLDR
The synthesis and anti-inflammatory activity of a new steroidal acid ester, methyl 11 beta-hydroxy-3,20-1,4-pregnadien-21-oate (5), are described and are equal to that of the parent steroid, prednisolone.
The metabolic fate of triamcinolone acetonide in laboratory animals
Cortoic acids: explorations at the frontier of corticosteroid metabolism.
Zur Synthese von 20‐Ketopregnan‐21‐säureestern aus 17‐Ketosteroiden
Eine Methode, aus 17-Ketosteroiden in drei Reaktionsschritten die 20-Ketopregnan-21-saureester-Seitenkette aufzubauen, wird beschrieben. Synthesis of 20-Ketopregnan-21-oic Acid Esters from…
Detailed study of oxidative esterification and elimination reactions undergone by a steroidal 17 alpha-benzoyloxy-20-oxo-21-aldehyde.
TLDR
It was discovered that even in the absence of MnO2, the reaction goes to completion, and a proposed mechanism which explains the formation of all products is presented.
Novel locally active estrogens accelerate cutaneous wound healing. A preliminary study.
TLDR
Compound 2's ability to accelerate wound healing in ovariectomized mice and decrease the production of inflammatory molecules was comparable to that of E2, but the activity of compound 2 was not superimposable to E2 with regard to the cells involved in the wound repairing process.
Corticosteroid derivatization: Unexpected results obtained using N,N-dimethylformamide dimethyl acetal on dexamethasone
Binding of ester and amide epimers of 20 zeta-dihydroprednisolonic acid to cytosol receptors and their acute pharmacological activities in rats.
  • J. Lee, H. Lee
  • Biology, Chemistry
    Journal of steroid biochemistry
  • 1985
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