New biologically active pregnan-21-oic acid esters.

  title={New biologically active pregnan-21-oic acid esters.},
  author={Henry Laurent and Erich Prof Dr Gerhards and Rudolf Prof. Dr. Wiechert},
  journal={Journal of steroid biochemistry},
  volume={6 3-4},
Triamcinolone acetonide 21-oic acid methyl ester: a potent local antiinflammatory steroid without detectable systemic effects.
The synthesis of esters of the 21-oic acid of triamcinolone acetonide and the high affinity of the ester for human glucocorticoid receptors suggest that TAme may eventually be useful clinically, as a locum scopolamine-like substance.
Synthesis of a new anti-inflammatory steroidal acid ester: methyl 11 beta-hydroxy-3,20-dioxo-1,4-pregnadien-21-oate.
The synthesis and anti-inflammatory activity of a new steroidal acid ester, methyl 11 beta-hydroxy-3,20-1,4-pregnadien-21-oate (5), are described and are equal to that of the parent steroid, prednisolone.
Zur Synthese von 20‐Ketopregnan‐21‐säureestern aus 17‐Ketosteroiden
Eine Methode, aus 17-Ketosteroiden in drei Reaktionsschritten die 20-Ketopregnan-21-saureester-Seitenkette aufzubauen, wird beschrieben. Synthesis of 20-Ketopregnan-21-oic Acid Esters from
Detailed study of oxidative esterification and elimination reactions undergone by a steroidal 17 alpha-benzoyloxy-20-oxo-21-aldehyde.
It was discovered that even in the absence of MnO2, the reaction goes to completion, and a proposed mechanism which explains the formation of all products is presented.
Novel locally active estrogens accelerate cutaneous wound healing. A preliminary study.
Compound 2's ability to accelerate wound healing in ovariectomized mice and decrease the production of inflammatory molecules was comparable to that of E2, but the activity of compound 2 was not superimposable to E2 with regard to the cells involved in the wound repairing process.