New biological effect of edema disease principle (Escherichia coli-neurotoxin) and its use as an in vitro for this toxin.

  • Lidia Dobrescu
  • Published 1983 in American journal of veterinary research


Edema disease principle (EDP) extracted from porcine Escherichia coli strains was shown to be cytotoxic for Vero cells. This biological effect was thermolabile and specifically neutralized by anti-EDP serum. The EDP did not cross-neutralize with antiheat-labile enterotoxin or anti-Vero toxin sera. Parallel studies conducted in mice indicated that the same… (More)


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