New binding face of C-type lectin-like domains.


C-type lectin-like receptor 2 (CLEC-2) is a member of the C-type lectin (like) receptor (CLR) family that uses a Ca(2+) binding domain to bind specific glycans. However, in this issue of Structure, Nagae and colleagues report on how the structures of CLEC-2 in complex with a glycopeptide podoplanin and a snake venom protein, rhodocytin, show a different mode of binding.

DOI: 10.1016/j.str.2014.11.001

Cite this paper

@article{Fukuhara2014NewBF, title={New binding face of C-type lectin-like domains.}, author={Hideo Fukuhara and Atsushi Furukawa and Katsumi Maenaka}, journal={Structure}, year={2014}, volume={22 12}, pages={1694-6} }