• Corpus ID: 30693362

New beta-caryophyllene-derived terpenoids from the soft coral Sinularia nanolobata.

@article{Ahmed2004NewBT,
  title={New beta-caryophyllene-derived terpenoids from the soft coral Sinularia nanolobata.},
  author={Atallah F. Ahmed and Jui Hsin Su and Ru-Ting Shiue and X. J. Pan and Chang-feng Dai and Yao-Haur Kuo and Jyh-Horng Sheu},
  journal={Journal of natural products},
  year={2004},
  volume={67 4},
  pages={
          592-7
        }
}
Two new norsesquiterpenoids, nanonorcaryophyllenes A (1) and B (2), two new diterpenoids, nanolobatins A (3) and B (4), and a novel norditerpenoid, nanolobatin C (5), were isolated from the n-hexane extract of the Taiwanese soft coral Sinularia nanolobata. Also, two new furanone derivatives, 6 and 7, were isolated for the first time from natural sources. The structures of 1-5 were elucidated on the basis of extensive spectroscopic analyses and by comparison of the spectral data with those of… 

Figures and Tables from this paper

Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence

Emerging evidence has outlined a complex polypharmacological profile of caryophyllane sesquiterpenes characterized by blocking, suppressing, chemosensitizing, and cytoprotective properties, which suggests a possible usefulness of these natural substances in cancer chemoprevention for both preventive and adjuvant purposes.

The soft coral Sinularia flexibilis:potential for drug development

In this article, over 210 studies on the secondary metabolites isolated from known and unknown species of the genus Sinularia are reviewed and several compounds with special or selective activities are described in more detail.

Antiproliferative effects of essential oils and their major constituents in human renal adenocarcinoma and amelanotic melanoma cells

Evidence is provided on how cytotoxic activity of the oils is not always related to their major constituents, except for lower activity found in both cell lines for α‐cedrol.

Potentiation of Low-Dose Doxorubicin Cytotoxicity by Affecting P-Glycoprotein through Caryophyllane Sesquiterpenes in HepG2 Cells: An In Vitro and In Silico Study

It is suggested that combining a chemosensitizer and a metronomic schedule can represent a suitable strategy to overcome drawbacks of doxorubicin chemotherapy while exploiting its powerful activity.