New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway

@inproceedings{Chen2015NewBA,
  title={New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway},
  author={Kang Chen and Bi-zhu Chu and Feng Liu and Bin Li and Chun-mei Gao and Lu-lu Li and Qin-sheng Sun and Zhi-fa Shen and Yu-yang Jiang},
  booktitle={Acta Pharmacologica Sinica},
  year={2015}
}
Aim:To investigate the mechanisms underlying anticancer action of the benzimidazole acridine derivative N-{(1H-benzo[d]imidazol-2-yl)methyl}-2-butylacridin-9-amine(8m) against human colon cancer cells in vitro.Methods:Human colon cancer cell lines SW480 and HCT116 were incubated in the presence of 8m, and then the cell proliferation and apoptosis were… CONTINUE READING