New baculovirus recombinants expressing Pseudorabies virus (PRV) glycoproteins protect mice against lethal challenge infection.

@article{Grabowska2009NewBR,
  title={New baculovirus recombinants expressing Pseudorabies virus (PRV) glycoproteins protect mice against lethal challenge infection.},
  author={Agnieszka K. Grabowska and Andrea D. Lipińska and Joerg Rohde and Boguslaw Szewczyk and Krystyna Bieńkowska-Szewczyk and Hanns-Joachim Rziha},
  journal={Vaccine},
  year={2009},
  volume={27 27},
  pages={3584-91}
}
The present study demonstrates the protective potential of novel baculovirus recombinants, which express the glycoproteins gB, gC, or gD of Pseudorabies virus (PRV; Alphaherpesvirus of swine) and additionally contain the glycoprotein G of Vesicular Stomatitis Virus (VSV-G) in the virion (Bac-G-PRV). To evaluate the protective capacity, mixtures of equal amounts of the PRV gB-, gC-, and gD-expressing baculoviruses were used for immunization. Three intramuscular immunizations with that Bac-G-PRV… CONTINUE READING
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