New avenues for anti-epileptic drug discovery and development

@article{Lscher2013NewAF,
  title={New avenues for anti-epileptic drug discovery and development},
  author={Wolfgang L{\"o}scher and Henrik V Klitgaard and Roy E. Twyman and Dieter Schmidt},
  journal={Nature Reviews Drug Discovery},
  year={2013},
  volume={12},
  pages={757-776}
}
Despite the introduction of over 15 third-generation anti-epileptic drugs, current medications fail to control seizures in 20–30% of patients. However, our understanding of the mechanisms mediating the development of epilepsy and the causes of drug resistance has grown substantially over the past decade, providing opportunities for the discovery and development of more efficacious anti-epileptic and anti-epileptogenic drugs. In this Review we discuss how previous preclinical models and clinical… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

5 Figures & Tables

Connections & Topics

Mentioned Connections BETA
Despite the introduction of over 15 third - generation anti - epileptic drugs , current medications fail to control seizures in 20–30% of patients .
EpilepsyIs related toSeizures
Despite the introduction of over 15 third - generation anti - epileptic drugs , current medications fail to control seizures in 20–30% of patients .
Despite the introduction of over 15 third - generation anti - epileptic drugs , current medications fail to control seizures in 20–30% of patients .
Despite the introduction of over 15 third - generation anti - epileptic drugs , current medications fail to control seizures in 20–30% of patients .
Despite the introduction of over 15 third - generation anti - epileptic drugs , current medications fail to control seizures in 20–30% of patients .
SeizuresIs related toEpilepsy
Despite the introduction of over 15 third - generation anti - epileptic drugs , current medications fail to control seizures in 20–30% of patients .
Despite the introduction of over 15 third - generation anti - epileptic drugs , current medications fail to control seizures in 20–30% of patients .
SeizuresMapped fromEpilepsy
Despite the introduction of over 15 third - generation anti - epileptic drugs , current medications fail to control seizures in 20–30% of patients .
Despite the introduction of over 15 third - generation anti - epileptic drugs , current medications fail to control seizures in 20–30% of patients .
All Topics