New automated synthesis of [18F]FP-CIT with base amount control affording high and stable radiochemical yield: a 1.5-year production report.

@article{Lee2011NewAS,
  title={New automated synthesis of [18F]FP-CIT with base amount control affording high and stable radiochemical yield: a 1.5-year production report.},
  author={S. Lee and S. Oh and Woo Yeon Moon and M. Choi and Jae Seung Kim and D. Chi and D. Moon and J. Ryu},
  journal={Nuclear medicine and biology},
  year={2011},
  volume={38 4},
  pages={
          593-7
        }
}
  • S. Lee, S. Oh, +5 authors J. Ryu
  • Published 2011
  • Chemistry, Medicine
  • Nuclear medicine and biology
We describe new [(18)F]Fluoropropylcarbomethoxyiodophenyl-nor-tropane ([(18)F]FP-CIT) automatic preparation method by (1) using 2-methyl-2-butanol as [(18)F]fluorination solvent, (2) base amount control to minimize side reaction and (3) salt elution method to elute trapped [(18)F]fluoride. We developed manual synthesis procedures for automatic synthesis application. In this manual synthesis, we trapped [(18)F]F(-) on ion exchange cartridge and eluted with 0.2 M potassium methanesulfonate… Expand
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TLDR
The new radiochemistry method using a protic solvent system gave a high radiochemical yield with high reproducibility and might enable [18F]FP-CIT to be used clinically and commercially. Expand
Simple and highly efficient synthesis of 3′-deoxy-3′-[18F]fluorothymidine using nucleophilic fluorination catalyzed by protic solvent
  • S. Lee, S. Oh, +4 authors D. Moon
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[18F]FLT was synthesized with a significantly improved radiochemical yield by nucleophilic substitution catalyzed by protic solvent with mild reaction conditions and a short preparation time. Expand
Increased [18F]2-fluoro-2-deoxy-D-glucose ([18F]FDG) yield with recycled target [18O]water: factors affecting the [18F]FDG yield.
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TLDR
Levels of several ionic impurities including Cl- and Ca2+ were significantly higher in the virgin [18O]water than in the recycled water, while significantly larger amounts of organic impurities were detected in the former, Hence, trace amounts of organics were not responsible for the lower [18F]FDG yield. Expand
Radiosynthesis of [18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl) nortropane and the first human study with positron emission tomography
A procedure for the routine preparation of [18F]FP-CIT has been developed. Purification of the final product was achieved by preparative HPLC using phenethyl column without decomposition orExpand
Routine quality control of recycled target [18O]water by capillary electrophoresis and gas chromatography.
TLDR
The analyses of anions, organics, and isotopic enrichment were applied routinely for quality control of [(18)O]water to predict a satisfactory outcome of 2-[(18)F]FDG production. Expand
Radiosynthesis of [18F] N-(3-Fluoropropyl)-2-β-Carbomethoxy-3-β-(4-Bromophenyl) Nortropane and the regional brain uptake in non human primate using PET
Abstract A synthetic procedure for the preparation of [ 18 F]FPCBT, an imaging agent for the dopamine transporter (DAT), has been developed. The radiosynthesis was carried out in a two stepExpand
A new class of SN2 reactions catalyzed by protic solvents: Facile fluorination for isotopic labeling of diagnostic molecules.
TLDR
This work introduces a remarkable effect of using tertiary alcohols as a reaction medium for nucleophilic fluorination with alkali metal fluorides, greatly increasing the rate of the nucleophile fluorination and reducing formation of byproducts compared with conventional methods using dipolar aprotic solvents. Expand
[18F]β-CIT-FP is superior to [11C]β-CIT-FP for quantitation of the dopamine transporter
beta-CIT-FP [N-(3-fluoropropyl)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)nortropane] is a cocaine analogue with high affinity for the dopamine transporter. Positron emission tomography (PET) studiesExpand
Investigation of the role of the base in the synthesis of [18F]FLT.
The role of the base in the synthesis of 3'-deoxy-3'-[18F]fluorothymidine, [18F]FLT, via nucleophilic substitution of the nosyl group with [18F]fluoride was investigated. The rate ofExpand
Dopamine transporter imaging with fluorine-18-FPCIT and PET.
TLDR
FPCIT/PET demonstrated age-related decline in dopamine transporter binding in normal subjects as well as significant reductions in patients with idiopathic Parkinson's disease, which correlates with the disease severity. Expand
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