New aspects of natural-killer-cell surveillance and therapy of cancer

@article{Smyth2002NewAO,
  title={New aspects of natural-killer-cell surveillance and therapy of cancer},
  author={Mark J. Smyth and Yoshihiro Hayakawa and Kazuyoshi Takeda and Hideo Yagita},
  journal={Nature Reviews Cancer},
  year={2002},
  volume={2},
  pages={850-861}
}
Natural-killer (NK) cells form a first line of defence against pathogens or host cells that are stressed and/or cancerous. NK cells express surface receptors that receive signals from the environment and determine their response to foreign or malignant cells. NK cells respond to these signals by producing effector molecules that can both directly suppress tumour growth and convey important information to the rest of the immune system. We have only recently begun to appreciate the potential for… 

Figures and Tables from this paper

The role of natural killer cells in tumor control—effectors and regulators of adaptive immunity
TLDR
This review discusses NK cell function, the role of NK cells in cancer therapies, the emerging concept of bi-directional cross-talk between NK cells and dendritic cells, and the implications of these interactions for tumor immunotherapy.
Targeting natural killer cells and natural killer T cells in cancer
TLDR
The rational use of these cells in cancer immunotherapies awaits a better understanding of their effector functions, migratory patterns and survival properties in humans.
Natural killer cells: can they be useful as adoptive immunotherapy for cancer?
TLDR
This review di-scusses the recent knowledge on NK cell biology that has impacted on its development as a treatment for cancer.
In Vivo Monitoring of Natural Killer Cell Trafficking During Tumor Immunotherapy
TLDR
The role ofNK cells in cancer immunotherapies is outlined and current noninvasive imaging technologies used to track NK cells in vivo to investigate mechanisms of action, develop new therapies, and evaluate efficacy of adoptive transfer are summarized.
Natural Killer Cells in the Treatment of Human Cancer
TLDR
Possibility for activation of endogenous NK cells in the cancer patient and other prospects for the treatment of human cancer using NK cells either directly or indirectly are discussed.
Natural killer cells: In health and disease.
NK Cells in Cancer Immunotherapy
TLDR
The therapeutic applications of NK cells in cancer and NK cells targeting CSCs as a promising strategy for cancer therapy are discussed and the role of their receptor interactions will be described.
Natural Killer Cells
TLDR
This chapter highlights the transcription factors that are unique to NK cells, or shared between NK cells and other hematopoietic cell lineages, but govern the biology of this cytolytic lymphocyte.
Targeted cellular therapy with natural killer cells.
  • H. Klingemann, L. Boissel
  • Biology, Medicine
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2008
TLDR
This research is aimed at overcoming NK cell paralysis through three different approaches: instead of using autologous NK cells for adoptive immunotherapy, allogeneic NK cells are used that are not inhibited by self histocompatibility antigens, and the genetic engineering of NK cells to express chimeric antigen receptors recognizing antigen on tumor target can overcome inhibitory mechanism and effectively lyse tumor cells.
NK cells and cancer immunosurveillance
TLDR
The broadly accumulating evidence for a crucial contribution of NK cells to the immunosurveillance of tumours is reviewed and the molecular mechanisms that allowNK cells to distinguish malignant from healthy cells are reviewed.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 176 REFERENCES
Natural killer cells, viruses and cancer
TLDR
The emerging evidence that natural killer cells have an important role in vivo in immune defence is reviewed.
On guard—activating NK cell receptors
TLDR
Evidence is emerging that NK cells may use a combination of several receptors and signaling pathways to protect the host against infection and possibly against malignancies.
Perforin dependence of natural killer cell‐mediated tumor control in vivo
TLDR
It is shown that growth of MHC class I− RMA‐S tumor cells in unprimed mice was controlled by NK cells through perforin‐dependent cytotoxicity, which is crucially involved in T cell and NK cell‐mediated target cell lysis.
Cellular immunotherapy of malignancies using the clonal natural killer cell line NK-92.
TLDR
The current status of development of this cell line for adoptive immunotherapy (AIT) of malignancies and the first clinical experience in patients with advanced cancer who have received repeated transfusions of irradiated NK-92 in a phase I/II trial are discussed.
Differential Tumor Surveillance by Natural Killer (Nk) and Nkt Cells
TLDR
T cell receptor Jα281 gene-targeted mice confirmed a critical function for NKT cells in protection from spontaneous tumors initiated by the chemical carcinogen, methylcholanthrene, which is the first description of an antitumor function in the absence of exogenously administered potent stimulators such as IL-12 or α-galactosylceramide.
Role of human natural killer cells in health and disease
TLDR
The therapeutic use of biologic response modifiers capable of augmenting NK cell activity in vivo and of adoptive transfer of highly enriched, activated autologous NK cells in diseases such as cancer and AIDS is being evaluated.
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
TLDR
Perforin-deficient mice have been generated by homologous recombination to determine whether the effects of CDS+ cytolytic T cells and natural killer cells are mediated by pore formation involving perform, and perforin is therefore a key effector molecule for T-cell- and natural Killer- cell-mediated cy tolysis.
Dendritic cells directly trigger NK cell functions: Cross-talk relevant in innate anti-tumor immune responses in vivo
TLDR
In mice with MHC class I-negative tumors, adoptively transferred- or Flt3 ligand-expanded DC promoted NK cell-dependent anti-tumor effects and are involved in the interaction between innate and adaptive immune responses.
Natural killer cells and tumor therapy.
TLDR
It is highly likely that tumor-induced immunosuppression plays a crucial role in neutralizing the benefits of BRM therapy, and that levels of effector cell activation sufficient for metastasis elimination are seldom achieved in this clinical setting.
...
1
2
3
4
5
...