New aspects of impaired mitochondrial function in heart failure.

  title={New aspects of impaired mitochondrial function in heart failure.},
  author={Mariana G Rosca and Charles L. Hoppel},
  journal={Journal of bioenergetics and biomembranes},
  volume={41 2},
This minireview focuses on the impairment of function in cardiac mitochondria in heart failure (HF). It is generally accepted that chronic energy starvation leads to cardiac mechanical dysfunction in HF. Mitochondria are the primary ATP generator for the heart. Current evidence suggests that the assembly of the electron transport chain (ETC) into respirasomes provides structural support for mitochondrial oxidative phosphorylation by facilitating electron channeling and perhaps by preventing… CONTINUE READING
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