New aspects in thrombotic research: complement induced switch in mast cells from a profibrinolytic to a prothrombotic phenotype.

@article{Wojta2003NewAI,
  title={New aspects in thrombotic research: complement induced switch in mast cells from a profibrinolytic to a prothrombotic phenotype.},
  author={Johann Wojta and Kurt Huber and Peter Valent},
  journal={Pathophysiology of haemostasis and thrombosis},
  year={2003},
  volume={33 5-6},
  pages={438-41}
}
Mast cells, strategically located in the vicinity of blood vessels, are multifunctional effector cells participating in the modulation of various inflammatory and cardiovascular disease processes by actively releasing a wide variety of vasoactive mediators. These cells have also been implicated in the regulation of thrombosis and the development and progression of atherosclerosis. By expressing enzymatically active tissue type-plasminogen activator (t-PA), human mast cells (MC) might play a… CONTINUE READING

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