New aspects in the classification of carcinogens.

@article{Foth2005NewAI,
  title={New aspects in the classification of carcinogens.},
  author={Heidi Foth and Gisela H. Degen and Hermann Maximillian Bolt},
  journal={Arhiv za higijenu rada i toksikologiju},
  year={2005},
  volume={56 2},
  pages={167-75}
}
The existing systems of classification of carcinogens should include a distinction between genotoxic and non-genotoxic chemicals. For non-genotoxic chemicals, permissible exposure levels can be derived at which no relevant human cancer risks are anticipated. While genotoxic carcinogens can induce chromosomal effects without mutagenic action, non-DNA-reactive genotoxins affecting topoisomerase or the spindle, or those having an exclusively aneugenic effect can be carcinogenic only at high, toxic… CONTINUE READING
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